Category: All Books

500 Years of the Royal College of Physicians

500 Years of the Royal College of Physicians

Edited by Linda Luxon and Simon Shorvon with Julie Beckwith
Third Millennium Publications, March 2018
ISBN: 978 1 781259 11 5
Pages: 192

Illustrations: Over 400


This large format hardback book narrates the history of the Royal College of Physicians, from its foundation and survival through a turbulent history to its position today as a leading international body for physicians. This book takes a chronological approach, showing the development of the college within the wider social landscape of great upheaval and innovation. Designed by Third Millennium Publications, it has striking photography and is heavily illustrated with specially curated archival images.

Table of Contents:


Chapter 1: Antecedents

Chapter 2: The foundation and rise of the College 1518-1660

Chapter 3: Calamity and conflict 1660-1740

Chapter 4: Enlightenment 1740-1820

Chapter 5: Reform and regulation 18820-1880

Chapter 6: Modernisation 1880-1948

Chapter 7: A brave experiment 1948-2018

Chapter 8: The College in a changing world

Appendices: Index, list of subscribers, picture credits.

Neurology: A Queen Square Textbook (2nd Edition)

Neurology: A Queen Square Textbook (2nd Edition)

Charles Clarke, Robin Howard, Martin Rossor, Simon Shorvon
Wiley Blackwell, 2016
ISBN: 978-1-118-48617-7
1096 pages


Neurology: A Queen Square Textbook, second edition, is a fully revised and updated companion that demonstrates the rapid pace of advancement within clinical neurology and applied neurosciences

  • A comprehensive and practical overview of current developments within clinical neurology, synthesising clinical neurology with translational research
  • Expertly edited and written by neurologists, neuroscientists and neurosurgeons working at Queen Square, advised by an distinguished International Editor team to present a global perspective
  • Introductory chapters summarise the basic sciences underpinning the practice of clinical neurology, including genetics, channelopathies, immunology, neurophysiology and neuropathology
  • All chapters fully revised and updated to reflect the increasing role of neurologists in acute care
  • Includes new contributions concerning major developments in the care of; stroke, epilepsy, dementia, Parkinson’s disease, multiple sclerosis, neuromuscular disease, headache, infections, spinal disease, cranial nerve disease, neuropsychiatry, neurogenetics, neuro-oncology, uroneurology, neuro-otology, neuro-ophthalmology, pain medicine, sleep medicine, metabolic disease, drugs and toxins, autonomic disease, systemic disease, and neurorehabilitation for dementia, epilepsy, headaches, neuro-genetics and many more

Table of Contents

1 Neurology Worldwide: The Epidemiology and Burden of Neurological Disease
Simon Shorvon

2 Nervous System Structure and Function
Charles Clarke and Roger Lemon

3 Mechanisms of Neurological Disease: Genetics, Autoimmunity and Ion Channels
Dimitri Kullmann, Henry Houlden and Michael Lunn

4 The Language of Neurology: Symptoms, Signs and Basic Investigations
Charles Clarke, Matthew Adams, Robin Howard, Martin Rossor, Simon Shorvon and Jason Warren

5 Stroke and Cerebrovascular Diseases
Nicholas Losseff, Matthew Adams, Martin M. Brown, Joan Grieve and Robert Simister

6 Movement Disorders
Kailash Bhatia, Carla Cordivari, Mark Edwards, Thomas Foltynie, Marwan Hariz, Prasad Korlipara, Patricia Limousin, Niall Quinn, Sarah Tabrizi and Thomas Warner

7 Epilepsy and Related Disorders
Simon Shorvon, Beate Diehl, John Duncan, Matthias Koepp, Fergus Rugg-Gunn, Josemir Sander, Matthew Walker and Tim Wehner

8 Dementia and Cognitive Impairment
Martin Rossor, John Collinge, Nick Fox, Simon Mead, Catherine Mummery, Jonathan Rohrer, Jonathan Schott and Jason Warren

9 Infection in the Nervous System
Robin Howard, Carmel Curtis and Hadi Manji

10 Nerve and Muscle Disease
Michael Lunn, Michael Hanna, Robin Howard, Matthew Parton, Shamima Rahman, Mary Reilly, Katie Sidle and Christopher Turner

11 Multiple Sclerosis and Demyelinating Diseases
Siobhan Leary, Gavin Giovannoni, Robin Howard, David Miller and Alan Thompson

12 Headache
Manjit Matharu, Paul Shanahan and Tim Young

13 Cranial Nerve Disorders
Jeremy Chataway, Charles Clarke, Robin Howard and Paul Jarman

14 Neuro-ophthalmology
James Acheson, Fion Bremner, Elizabeth Graham, Robin Howard, Alexander Leff, Gordon Plant, Simon Shorvon and Ahmed Toosy

15 Neuro-0tology: Problems of Dizziness, Balance and Hearing
Rosalyn Davies, Linda M. Luxon, Doris ]Eva Bamiou and Adolfo Bronstein

16 Spinal Column and Spinal Cord Disorders
Simon Farmer and David Choi

17 Cerebellar Ataxias and Related Conditions
Nicholas W. Wood

18 Restorative Neurology, Rehabilitation and Brain Injury
Richard Greenwood, Diana Caine, Ulrike Hammerbeck, Alexander Leff, Diane Playford, Valerie Stevenson and Nick Ward

19 Toxic, Metabolic and Physical Insults to the Nervous System and Inherited Disorders of Metabolism
Robin Howard, Jeremy Chataway, Mark Edwards, Simon Heales, Robin Lachmann, Alexander Leff and Elaine Murphy

20 Disorders of Consciousness, Intensive Care Neurology and Sleep
Robin Howard, Sofia Eriksson, Nicholas Hirsch, Neil Kitchen, Dimitri Kullmann, Christopher Taylor and Matthew Walker

21 Neuro-oncology
Jeremy Rees, Robert Bradford, Sebastian Brandner, Naomi Fersht, Rolf Jäger and Elena Wilson

22 Neuropsychiatry
Eileen Joyce

23 Pain
Paul Nandi

24 Autonomic Aspects of Neurology
Christopher Mathias, Gordon Ingle and Valeria Iodice

25 Uroneurology
Jalesh Panicker

26 Systemic Conditions and Neurology
David Werring, Robin Howard and Simon Shorvon

Index 1029

Physicians and War

Physicians and War

Humphrey Hodgson and Simon Shorvon
Little Brown 2016
ISBN-10: 1408706288; ISBN9781408706282
112 pages


The Royal College of Physicians celebrates its 500th anniversary in 2018, and to observe this landmark is publishing a series of ten books. Each of the books focuses on fifty elements that have contributed to making the RCP what it is today.  This, the fourth book, outlines some of the effects of war on the College as an institution, on it’s buildings and especially on its members and fellows. Medicine can profoundly change the fortunes of those engaged in war, and war also greatly changes medicine. It creates new diseases, leads to medical innovation and advances in therapy, and has also stimulated new approaches to the organisation of medical care. This book is a brief exposition on aspects of the complex interface of war and medicine, and the crucial role played by the College and its physicians in the medicine of war.

Table of Contents


The turbulent seventeenth century

Napoleonic wars and the alter nineteenth century

World War I

World War II


The End of Epilepsy?: A history of the modern era of epilepsy research 1860-2010

The End of Epilepsy?: A history of the modern era of epilepsy research 1860-2010

Dieter Schmidt and Simon Shorvon
Oxford University Press, 2016
ISBN-10: 0198725906; ISBN-13: 9780198725909
208 pages


Epilepsy is more than just a physical condition, the fact of simply having epileptic seizures, it has cultural, geographic and historical meaning and significance which go beyond that of a neurological disorder, and which defy a single perspective. The End of Epilepsy? is a beautifully illustrated, authoritative, and engaging history of medical developments during the modern era of epilepsy, which began with the introduction of Bromides and Hughlings-Jacksons definition of epilepsy in 1860.

Table of Contents

1: What is epilepsy?
2: Attitudes
3: The pharmaceutical phoenix rises
4: Modern blockbusters
5: Resecting epilepsy
6: The dark side of epilepsy
7: Culs-de-sac and bureaucracies
8: Is the end of epilepsy in sight?
Appendix: Dating epilepsy




Epilepsy: A Global Approach

Epilepsy: A Global Approach

Editors: Krishnamoorthy ES, Shorvon SD, Schachter S
Cambridge University Press; 1 edition (6 April 2017)
ISBN-10: 1107035376, ISBN-13: 978-1107035379
232 pages


A multidisciplinary approach to epilepsy compares and contrasts scientific knowledge, clinical experience and social consciousness between Western and non-Western cultures, enhancing transcultural understanding and providing a paradigm for an integrative, truly global health policy for this disorder. Topics covered include pharmacological and non-pharmacological management of epilepsy; care models and traditional medical systems; service organization in resource-limited countries; cultural perspectives on consequences of epilepsy; social, anthropological, economic, political, and spiritual issues related to living with epilepsy; infectious and non-infectious causes and risk-factors; region-specific syndromes. Uniquely drawing attention to both a medical perspective and the burden of living with epilepsy, this is a must-have reference work for epileptologists, neurologists, epidemiologists, medical policymakers and health administrators in both the developed and developing world.

Status Epilepticus: Its Clinical Features and Treatment in Children and Adults

Status Epilepticus: Its Clinical Features and Treatment in Children and Adults

Paperback: 404 pages
Publisher: Cambridge University Press; 1 edition (November 2, 2006)
Language: English
ISBN-10: 0521031141
ISBN-13: 978-0521031141

Status epilepticus, the maximum expression of epilepsy, is a distinctive condition, much more than simple a severe version of ordinary epilepsy. This is the definitive reference work on the subject, taking a modern look at the clinical features, pathophysiology and treatment of status, in both children and adults.

All forms of status are considered, including the classical convulsive (grand mal) type, the less well-understood yet common and fascinating nonconvulsive variants, boundary syndromes and also pseudostatus epilepticus. The history, clinical aspects, treatment and outcome of each form are explored in their scientific content, accounting for research findings in the fields of epidemiology, neurophysiology, neuroanatomy, neuropathology, neurochemistry and neuropharmacology. Received ideas are examined critically, the existing schemes of classification revised, and current practice is challenged where it seems inadequate.

Treatment is dealt with in depth, and schemes of management outlined for both convulsive and nonconvulsive forms. For each drug used in status, a systematic review is given of the pharmacology, clinical and toxic effects in status, administration and dosage. Summary tables outline key clinical information.

The text is based on extensive clinical experience of the author, and a practical and theoretical perspective is taken throughout. The world literature is expertly marshalled to provide a comprehensive review of the topic in all its aspects. The book is therefore both a reference work and a practical guide, useful for a wide range of clinicians, neurologists, psychiatrists, paediatricians, other specialists and generalists, and all those dealing with emergency and intensive care medicine.


1: The concept of status epilepticus and its history
Pre-history of status epilepticus
Origins of status epilepticus
Classical descriptions of status epilepticus
Era of electroencephalography
Les Colloques de Marseille, and the definition and classification of status epilepticus

2: Definition, classification and frequency of status epilepticus
Definition of status epilepticus
Classification of status epilepticus
A new classification of status epilepticus
Frequency of status epilepticus
Population estimates of the frequency of status epilepticus

3: Clinical forms of status epilepticus
Status epilepticus confined to the neonatal period
Neonatal status epilepticus
Status epilepticus in neonatal epilepsy syndromes
Status epilepticus confined largely to infancy and childhood
Infantile spasm (West syndrome)
Febrile status epilepticus
Status in childhood myoclonic epilepsies
Status epilepticus in the benign childhood epilepsy syndromes
Electrical status epilepticus during slow wave sleep
Syndrome of acquired epileptic aphasia (Landau-Kleffner or Worster-Drought syndrome)
Status epilepticus occurring in late childhood and adult life
Tonic-clonic status epilepticus
Absence status epilepticus
Epilepsia partialis continua
Myoclonic status epilepticus in coma
Specific forms of status epilepticus in mental retardation
Other syndromes of myoclonic status epilepticus
Nonconvulsive simple partial status epilepticus
Complex partial status epilepticus
Boundary conditions
Status epilepticus confined to adult life
De novo absence status epilepticus of late onset
Pseudostatus epilepticus

4: Neurophysiology, neuropathology and neurochemistry of status epilepticus
Experimental neurophysiology of status epilepticus
Neuropathology of status epilepticus
Neurochemistry of status epilepticus

5: Emergency treatment of status epilepticus
General measures
Antiepileptic drug pharmacokinetics in status epilepticus
Drug absorption
Drug distribution, metabolism and excretion
Blood levels and interactions
Ideal antiepileptic drug in tonic-clonic status epilepticus
Stages of drug treatment in tonic-clonic status epilepticus, and drug treatment regimens
Failure of antiepileptic drug treatment
Antiepileptic drugs used in status epilepticus
Premonitory status epilepticus
Early and established status epilepticus
Chlormethiazole (chlomethiazole)
Lignocaine (lidocaine)
Phenobarbitone (phenobarbital)
Stage of refractory status epilepticus: general anaesthesia
Thiopentone sodium (thiopental sodium)
Pentobarbitone sodium (pentobarbital sodium)
Other drugs used in status epilepticus
Emergency treatment of other forms of status epilepticus
Prologue to therapy in status epilepticus

6: Prognosis and outcome of status epilepticus
Outcome of tonic-clonic status epilepticus (including generic studies of status epilepticus)
Outcome of other syndromes of status epilepticus

The Treatment of Epilepsy (4th Edition)

The Treatment of Epilepsy (4th Edition)

Simon Shorvon, Emilio Perucca, Jerome Engel (eds) 
2016, Wiley-Blackwell | ISBN 978-1-118-93700-6 | pp 1072

The Treatment of Epilepsy, fourth edition, is a comprehensive reference and clinical guide to the
pharmacological, medical and surgical options available in the treatment of epilepsy.
Its features include:

The text is compiled by a group of internationally renowned editors and contributors and
is now in full color and extensively illustrated
The first two sections cover the background to, and principles of, treatment in different
clinical situations
Section three comprises a series of systematic reviews of contemporary drug therapy,
devoting one chapter to each anti-epileptic drug and covering all clinically-relevant aspects
Section four focuses on the surgical options, devoting individual chapters to each of the
modalities of presurgical assessment and to each surgical operation or approach
This 4th edition is extensively revised incorporating the many recent developments in
therapy, and comprises 81 chapters from world experts from 18 countries



List of Contributors v
Preface to the Fourth Edition ix
Preface to the First Edition xi

Historical Introduction
The Drug Treatment of Epilepsy from 1857 to 2015 xiii
Simon Shorvon

Section I – Introdution
1 Definition (Terminology) and Classification in Epilepsy: A Historical Survey and Current Formulation,
with Special Reference to the ILAE 1
Simon Shorvon

2 Differential Diagnosis of Epilepsy 24
Mark Cook

3 Mechanisms of Epileptogenesis 38
Giuliano Avanzini and Silvana Franceschetti

4 Antiepileptic Drug Discovery 52
H. Steve White and Melissa Barker-Haliski

5 Antiepileptic Drug Development 61
Dieter Schmidt

6 Mechanisms of Antiepileptic Drug Action 75
Matthew C. Walker and Rainer Surges

7 Mechanisms of Drug Resistance and Tolerance 92
Wolfgang Löscher and Dieter Schmidt

8 Epilepsy Biomarkers 103
Jerome Engel, Jr. and Asla Pitkänen

Section II – Principles of Medical Management
9 General Principles of Medical Management 110
Emilio Perucca

10 Pharmacokinetic Optimization of Therapy 124
Svein I. Johannessen, Cecilie Johannessen Landmark and Emilio Perucca

11 Management of Chronic Active Epilepsy in Adults 139
Simon Shorvon

12 Management of Epilepsy in Remission 148
Patrick Kwan, Howan Leung and Xiaoting Hao

13 Management of Epilepsy in Neonates and Infants 156
Elissa G. Yozawitz and Solomon L. Moshé

14 Management of Childhood Epilepsy Syndromes 174
Colin D. Ferrie

15 Management of Epilepsy in People with Intellectual Disabilities 193
Eylert Brodtkorb

16 Management of Epilepsy in the Elderly 205
Hiba Arif Haider and Lawrence J. Hirsch

17 Emergency Treatment of Seizures and Status Epilepticus 221
Matthew C. Walker and Simon Shorvon

18 Management of Medical Comorbidity Associated with Epilepsy 245
Gagandeep Singh

19 Psychiatric Features of Epilepsy and their Management 259
Brent Elliott and Simon Shorvon

20 Prevention and Management of Side-effects of Antiepileptic Drugs 275
Gaetano Zaccara and Piero Perucca

21 Ketogenic Diets 288
Eric H. Kossoff and Courtney A. Haney

22 Complementary and Alternative Treatments for Epilepsy 298
Sallie Baxendale

23 Reproductive Aspects of Epilepsy Treatment 311
Torbjörn Tomson

24 Genetic Counselling in Epilepsy 323
Federico Zara

25 Drug Interactions 344
Edoardo Spina and Domenico Italiano

26 Medical Treatment of Epilepsy in Resource-Poor Countries 360
Patrick Adjei

Section III – Antiepileptic Drugs
27 Introduction to the Choice of Antiepileptic Drugs 365
Emilio Perucca

28 Acetazolamide 376
Miri Y. Neufeld

29 Adrenocorticotropic Hormone and Corticosteroids 388
Federico Vigevano and Maria Roberta Cilio

30 Benzodiazepines Used in the Treatment of Epilepsy 398
Eugen Trinka and Francesco Brigo

31 Brivaracetam 418
Joseph D’Souza and Emilio Perucca

32 Carbamazepine 431
Torbjörn Tomson and Svein I. Johannessen

33 Eslicarbazepine Acetate 447
Meir Bialer and Christian Elger

34 Ethosuximide 460
Tracy A. Glauser and Emilio Perucca

35 Felbamate 472
Ilo E. Leppik and James R. White

36 Gabapentin 479
Ernest R. Somerville, Andrew W. Michell and Arjune Sen

37 Lacosamide 489
Rajesh Sachdeo and Roopal Karia

38 Lamotrigine 498
Awais Riaz and Fumisuke Matsuo

39 Levetiracetam 516
Derek J. Chong and Jacqueline A. French

40 Oxcarbazepine 533
Edward Faught and Hyunmi Kim

41 Perampanel 546
Martin Brodie

42 Phenobarbital, Primidone and Other Barbiturates 555
Roberto Michelucci and Elena Pasini

43 Phenytoin 574
Mervyn J. Eadie

44 Piracetam 589
Simon D. Shorvon

45 Pregabalin 595
Sylvain Rheims and Philippe Ryvlin

46 Retigabine 606
Michel Baulac

47 Rufinamide 617
Victor Biton

48 Stiripentol 628
Tapani Keränen

49 Tiagabine 633
Reetta Kälviäinen

50 Topiramate 642
J. Helen Cross and Catherine J. Riney

51 Valproate 652
Anthony G. Marson and Graeme J. Sills

52 Vigabatrin 667
Günter Krämer and Gabriele Ch. Wohlrab

53 Zonisamide 680
Michel Baulac

54 Other Less Commonly Used Antiepileptic Drugs 689
Martin Holtkamp

55 Drugs in Clinical Development 701
Norman Delanty and H. Steve White

Section IV – Presurgical Assessment and Epilepsy Surgery
56 Overview of Surgical Treatment for Epilepsy 709
Jerome Engel, Jr.

57 Scalp EEG in the Epilepsy Surgery Evaluation 723
Christine B. Baca and John M. Stern

58 Invasive EEG in Presurgical Evaluation of Epilepsy 733
Dennis Spencer, Dang K. Nguyen and Adithya Sivaraju

59 MEG in Epilepsy Surgery Evaluation 756
Hermann Stefan and Paul Boon

60 MRI in Presurgical Evaluation 764
Christian E. Elger and Bernd Weber

61 PET and SPECT in Presurgical Evaluation of Epilepsy 775
Karolien Goffin and Wim Van Paesschen

62 Special Neurophysiological Techniques 787
François Mauguière and Julien Jung

63 Neuropsychological Testing in Presurgical Evaluation 804
Marilyn Jones-Gotman and Gail L. Risse

64 Presurgical Psychiatric Evaluation 817
Andres M. Kanner

65 Mesial Temporal Lobe Surgery and Other Lobar Resections 829
James Leiphart and Itzhak Fried

66 Resective Surgery of Neoplasms 842
Nicholas M. Wetjen and Gregory D. Cascino

67 Resective Surgery of Vascular and Infective Lesions for Epilepsy 858
Christopher E. Uff and Neil D. Kitchen

68 Surgery of Developmental Anomalies Causing Epilepsy 878
Ahyuda Oh, Joshua J. Chern and Youssef G. Comair

69 Hemispheric Operations for Epilepsy 887
Georg Dorfmüller, Christine Bulteau and Olivier Delalande

70 Corpus Callosum Operations 895
David W. Roberts

71 Hypothalamic Hamartoma 903
John F. Kerrigan

72 Multiple Subpial Transection 916
Adriana Bermeo-Ovalle and Michael C. Smith

73 Awake Surgery for Epilepsy 922
Webster H. Pilcher

74 Epilepsy Surgery in Children 931
Jason S. Hauptman and Gary W. Mathern

75 Complications of Epilepsy Surgery 941
Charles E. Polkey

76 Anaesthesia for Epilepsy Surgery 952
Barbara M. Van de Wiele

77 Vagus and Trigeminal Nerve Stimulation 959
Steven C. Schachter

78 Brain Stimulation for Epilepsy 967
Gregory K. Bergey and Robert S. Fisher

79 Non-Resective Approaches for Medically Intractable Epilepsy 980
Thomas J. Gianaris, Andrea G. Scherer and Nicholas M. Barbaro

80 Future Focal Treatment Approaches to Epilepsy 987
Laura Mantoan Ritter and Hannah Cock

81 Epilepsy Surgery in Countries with Limited Resources 999
Andre Palmini and Kurupath Radhakrishnan


Index 1008

Oxford Textbook of Epilepsy and Epileptic Seizure

Oxford Textbook of Epilepsy and Epileptic Seizure


Practical, easy-to-read text with a clinical focus
Written by internationally-renowned specialists, with an emphasis on the personal experience of the authors
Published in concurrent print and online versions to enhance the learning experience


400 pages; 10.9 x 8.6; ISBN13: 978-0-19-965904-3ISBN10: 0-19-965904-4


The book has a distinguished faculty with experts from five continents. The list of contents is as follows:

1. Neurophysiology of epilepsy: Florin Amzica
2. Neurogenetics of epilepsy: Renzo Guerrini and Elena Parrini
3. Neurochemistry of epilepsy: Edward Hogan, Lawrence Eisenman, and B. Keith Day
4. Developmental neurobiology, neuroanatomy, and neuropathology of epilepsy , Ingmar Blumcke
5. Definitions and epidemiology of epilepsy: Shichuo Li, Ding Ding, and Jianzhong Wu
6. The causes of epilepsy: Simon Shorvon
7. Classification, clinical symptoms, and syndromes: Renzo Guerrini and Carmen Barba
8. Differential diagnosis of epilepsy: Kristina Malmgren, Markus Reuber, and Richard Appleton
9. EEG in the investigation of epilepsy: Stephan U. Schuele, Adriana C. Bermeo, and Samden D. Lhatoo
10. Neuroimaging in the Investigation of epilepsy: Trevor T.-J. Chong and Mark Cook
11. The biochemical, haematological, histological, immunological, and genetic investigation of epilepsy: Simon Shorvon
12. Non-pharmacological therapy of epilepsy: Peter Wolf, Katia Lin, and Marina Nikanorova
13. Reproductive aspects of epilepsy: Michael R. Johnson and John J. Craig
14. Neonatal seizures and infantile onset epilepsies: Elia Pestana Knight and Ingrid E. B. Tuxhorn
15. Epileptic encephalopathies: Renzo Guerrini and Carla Marini
16. Principles of treatment of epilepsy in children and adolescents: Renzo Guerrini
17. Epilepsy in learning disability: Tom Berney and Shoumitro Deb
18. Epilepsy in the elderly: Trevor T.-J. Chong and Wendyl D’Souza
19. Psychiatric co-morbidity in epilepsy: Marco Mula
20. Epilepsy due to traumatic brain injury (TBI), cerebrovascular disease (CVD), central nervous system (CNS) infections and brain tumours: Gagandeep Singh, J. M. K. Murthy, and Ashalata Radhakrishnan
21. Epilepsy in renal, hepatic, and other conditions: Aidan Neligan
22. Management of patients with first seizure and early epilepsy: Zachary Grinspan and Shlomo Shinnar
23. The medical treatment of chronic active epilepsy: Simon Shorvon
24. Epilepsy in remission: Jerry J. Shih
25. Drug interactions: Philip N. Patsalos
26. The pharmacokinetics and clinical therapeutics of the antiepileptic drugs: Mark Cook and Simon Shorvon
27. Principles of epilepsy surgery: Samden D. Lhatoo
28. Resective surgery of temporal lobe epilepsy: Simon V. Liubinas, Andrew P. Morokoff, and Terence J. O’Brien
29. Resective surgery of extra-temporal epilepsy: Shahram Amina and Hans O. Luders
30. Vagal berve stimulation and deep brain stimulation in epilepsy: Paul A.J.M. Boon and Kristl E. Vonck
31. Other surgeries for epilepsy and new approaches: Kitti Kaiboriboon and Samden Lhatoo
32. Management of seizures and of epilepsy in the emergency department: Andrea O. Rossetti
33. The management of status epilepticus on the intensive care unit: Erich Schmutzhard and Bettina Pfausler
34. Epilepsy and employment: Ann Jacoby
35. Sexual and emotional behaviour in epilepsy: Sarah J. Wilson and Jessie Bendavid
36. Cognition and memory in adults: Sallie Baxendale
37. Legal aspects of epilepsy and epilepsy and driving: Morris Odell

The Beginning of the End of the Falling Sickness: Epilepsy and its Treament in London 1860-1910

The Beginning of the End of the Falling Sickness: Epilepsy and its Treament in London 1860-1910

Simon Shorvon and Louise Shepherd

2012, Simon Shorvon. pp64

This volume was prepared for the 10th European Congress of Epileptology (ECE) of the International League Against Epilepsy (ILAE) was held in London 30 September to 4 October 2012 at the ExCel Centre. It is to accompany the small historical exhibition was compiled illustrating the evolution of the study of epilepsy in London between the years 1860 and 1910.

Around 1860, considerable progress was made in the study of epilepsy, and it was from then, over a period of about 50 years, that epilepsy largely shed its skin of superstition and emerged in its modern form. London was a major centre for this transformation. It was in London that a number of physicians and surgeons changed the conceptual basis of epilepsy, the first effective drug treatment of epilepsy was discovered, the first hospital was established specifically for the treatment of epilepsy, the cortical localisation of epileptic activity was demonstrated, and the first surgical operation for epilepsy was carried out. Furthermore, through these activities epilepsy rose from being a condition of general obscurity to become the hierophant of brain disease, and a central concern of neurology, medicine and neuroscientific thought. There was of course much work in other centres, largely in Europe, and considerable traffic of ideas and people around Europe and the United States of America; but, for this short period, London remained the main focus for both clinical and theoretical advances in the field of epilepsy. This book outlines the history of the study of epilepsy in London in this period, and the text includes photographs of contemporary documents and illustrations.



1. Introduction
2. Epilepsy in London in 1860, new hospitals and early
3. Epilepsy physicians 1
4. John Hughlings Jackson (1835 – 1911)
5. Sir David Ferrier (1843 – 1928)
6. Sir William Gowers (1845 – 1915)
7. Sir Victor Horsley (1857 – 1916)
8. Epilepsy in London by 1910 1
9. Bromides and other medicinal treatments

The Causes of Epilepsy: Common and Uncommon Causes in Adults and Children

The Causes of Epilepsy: Common and Uncommon Causes in Adults and Children

Edited by: Simon D. Shorvon, Frederick Andermann, Renzo Guerrini 

Cambridge University Press, Cambridge. 

ISBN 978-1-4051-8383-3 

pp 790 

Causation is an aspect of epilepsy neglected in the scientific literature and in the conceptualization of epilepsy at a clinical and experimental level. It was to remedy this deficiency that this book was conceived. The book opens with a draft etiological classification that goes some way to filling the nosological void. The book is divided into three etiological categories: idiopathic, symptomatic, and provoked epilepsies. Each chapter considers topics in a consistent fashion, dealing with the phenomenon of epilepsy in each etiology, including its epidemiology, clinical features and prognosis, and any specific aspects of treatment. The book is a comprehensive reference work, a catalogue of all important causes of epilepsy, and a clinical tool for all clinicians dealing with patients who have epilepsy. It is aimed at epileptologists and neurologists and provides a distillation of knowledge in a form that is helpful in the clinical setting.

The authorship is drawn from leading international authorities in the field providing an authoritative resource. It provides extensive coverage of the causes of epilepsy in all age groups, both common and rare, in over 100 chapters, and extensive illustrations and tables.



Jerome Engel

Sir John Bell

Simon Shorvon

Section 1 – Introdution
1. Historical introduction
Simon Shorvon

2. The etiological classification of epilepsy
Simon Shorvon

3. Epileptogenesis in idiopathic epilepsy
Snezana Maljevic , Holger Lerche

4. Mechanisms of epileptogenesis in symptomatic epilepsy
Mark Cook

Section 2 – Idiopathic Epilepsy
5. Introduction to the concept of genetic epilepsy
Renzo Guerrini , Simon Shorvon, Frederick Andermann, Eva Andermann

Subsection 2.1 – Pure epilepsies due to single-gene disorders
6. The genetic contribution to epilepsy: the known and missing heritability
Michael Johnson

7. Benign Familial Neonatal seizures
Perrine Plouin

8. Autosomal dominant nocturnal frontal lobe epilepsy
Paolo Tinuper, Francesca Bisulli

9. Genetic epilepsy with febrile seizures plus
Ingrid Scheffer, Yue-Hua Zhang

10. Severe myoclonic epilepsy of infancy or Dravet Syndrome
Carla Marini , Renzo Guerrini
11. Benign adult familial myoclonic epilepsy
Teiichi Onuma
Subsection 2-2 – Pure epilepsies with presumed complex inheritance
12. Idiopathic Generalised Epilepsy
Carlo Marini, Renzo Guerrini

13. Benign Partial Epilepsies of Childhood
Roberto Caraballo, Natalio Fejerman

Section 3 – Symptomatic Epilepsy
14. Introduction to the concept of symptomatic epilepsy
Simon Shorvon

Subsection 3.1 – Epilepsy Syndromes
15. West Syndrome and Lennox-Gastaut Syndrome
Renzo Guerrini, Carla Marini

Subsection 3.2 – Progressive myoclonic epilepsies
16. Unverricht-Lundborg disease
Maria Lehtinen, Anna-Elina Lehesjoki, Reetta Kalviainen

17. Dentato-rubro-pallido-luysian atrophy (DRPLA)
Teiichi Onuma

18. Lafora body disease
Anna Jansen

19. Epilepsy in mitochondrial cytopathies
Laurence Bindoff, Bernt Engelsen

20. Neuronal ceroid lipofuscinosis
Ruth Williams

21. Sialidosis and Gaucher disease
Silvana Franceschetti, Laura Canafoglia

22. Action myoclonus-renal failure syndrome
Eva Andermann

23. Progressive myoclonic epilepsies: other rarer causes
Frederick Andermann, Eva Andermann

Subsection 3.3 – Neurocutaneous syndromes
24. Tuberous Sclerosis complex
Catherine Chu-Shore, Elizabeth Thiele

25. Neurofibromatosis
Rosalie Ferner and Margaret Jackson

26. Sturge-Weber Syndrome
Alexis ArzimanoglouLeni Panagiotakaki

27. Other neurocutaneous syndromes
Ignacio Pascual-Castroviejo

Subsection 3.4 – Other single-gene disorders with epilepsy as a prominent symptom
28. Angelman syndrome
Bernard Dan, Stewart Boyd

29. Lysosomal disorders and Menkes syndrome
Edwin Kolodny, Swati Sathe

30. Neuroacanthocytosis
Anna Jansen

31. Organic acid, amino acids and peroxisomal disorders.
Maria Alice Donati, Serena Gasperini, Renzo Guerrini

32. Porphyria
Geoffrey Dean, Simon Shorvon

33. Pyridoxine-dependant epilepsy.
Sidney Gospe

34. Rett Syndrome and MECP2 and CDKL5 genotypes
Daniel Glaze

35. Urea cycle disorders
Linda Huh, Kevin Farrell

36. Wilson disease
JM Walshe

37. Disorders of cobalanin and folate metabolism
Michael Shevell, David Watkins, David Rosenblatt

38. Other single gene disorders
Vincent Navarro, Frédéric Sedel

Subsection 3.5 – Disorders of chromosome structure
39. Down syndrome.
Nadia Bahi-Buisson, Monika Eisermann, Olivier Dulac

40. Fragile X syndrome.
Irissa Devine, Carl Stafstrom

41. 4p (Wolf-Hirschhorn) syndrome
Agatino Battaglia

42. Inverted duplicated chromosome 15 (isodicentric chromosome 15)
Agatino Battaglia

43. Ring chromosome 20
Geneviève Bernard, Frederick Andermann

Subsection 3.6 – Developmental anomalies of cerebral structure (cortical dysplasia)
44. Hemimegalencephaly
M Scott Perry, Michael Duchowny

45. Focal cortical dysplasia and related variants
Ruben Kuzniecky

46. Agyria- pachygyria band spectrum
Elena Parrini, Renzo Guerrini

47. Agenesis of the corpus callosum
Dorothy Jones-Davis, Yolanda Lau, Elliott Sherr / Jones Davies

48. Polymicrogyria and schizencephaly
Renzo Guerrini, Carman Barba

49. Periventricular nodular heterotopia
Rahul Tathakrishnan, Yahya Aghakhani, François Dubeau

50. Microcephaly
Elizabeth Ross

51. Arachnoid cysts
Concezio Di Rocco, Gianpiero Tamburrini

52. Malformations of human cerebral cortex
Waney Squier

Subsection 3.7 – Hippocampal sclerosis and prenatal and perinatal injury
53. Hippocampal sclerosis
Fernando Cendes, Márcia Morita

54. Neonatal and postneonatal epilepsy – causes
Lei Mizrahi, Kevin Chapman

55. Cerebral palsy
Sameer Zuberi, Andreas Brunklaus

56. Vaccination and immunization
Simon Shorvon

Subsection 3.8 – Cerebral trauma
57. Open head injury
Flavio Giordano, Barbara Spacca, Lorenzo Genitori

58. Closed head injury
Manuel Muria-Fernandez, Jorge Borneo, Robert Teasell

59. De novo epilepsy after neurosurgery
Charles Polkey

60. Epilepsy after epilepsy surgery
Andre Palmini

61. Non-accidental braininjury
Renzo Guerrini, Alessio De Ciantis

Subsection 3.9 – Cerebral tumor
62. Glioma
William Gray, Henry Bulstrode

63. Ganglioglioma, Dysembryoplastic Neuroepithelial tumour and related tumours
Thomas Jacques, William Harkness

64. Hypothalamic hamartoma and gelastic epilepsy
John Kerrigan

65. Meningiomas
Sumeet Vadera, William Bingaman

66. Metastatic disease
Rolando Del Maestro, Abdulrahman Sabbagh, Ahmed Lary, Marie-Christine Guilot

Subsection 3.10 – Cerebral infection
67. Viral encephalitis
Jane Adcock

68. Bacterial meningitis and focal suppurative intracranial infections in children
Suresh Pujar, Richard Chin

69. Bacterial meningitis and pyogenic abscess in adults
Lina Nashef, Fahmida Chowdhury

70. Malaria
Charles Newton

71. Neurocysticercosis
Hector Garcia

72. Other Parasitic diseases
Manish Modi, Gagandeep and Singh

73. Tuberculosis
Nadir Bharucha, Roberta Raven, Vivek Nambiar

74. HIV infection
P Satischandra, S Sinha

75. Emerging and less common central nervous system viral encephalitides
HT Chong, CTTan

Subsection 3.11 – Cerebrovascular disease
76. Cerebral haemorrhage
Henry Dinsdale

77. Cerebral infarction and occult degenerative cerebrovascular disease
Ruth Namire, R Eugene Ramsey

78. Arteriovenous malformations
SA Tharin, Autumn Klein, Robert Friedlander

79. Cavernous maalformations
Adrian Siegel

80. Other vascular disorders
Leif Gjerstad, Erik Taubøll

Subsection 3.12 – Cerebal immunological disorders
81. Rasmussen encephalitis and related conditions
Antonio Gambardella, Frederick Andermann

82. Systemic lupus erythematosus and other collagen vascular diseases
Rolando Cimaz, Andrea Taddio

83. Inflammatory and immunological diseases of the central nervous system
Michael Lunn

Subsection 3.13 – Other cerebral disorders
84. Psychiatric disorders
Brent Elliott, John O’Donavan

85. Mutiple sclerosis and other acquired demyelinating diseases
Mark Manford

86. Hydrocephalus, porencephaly
Pierangelo Veggiotti, Frederica Teutonico

87. Alzheimer disease and other adult degenerative disorders
Sigmund Jenssen, Kandan Kulanfaivel

Section 4 – Provoked Epilepsies
88. Introduction to the concept of provoked epilepsy
Simon Shorvon, Renzo Guerrini, Frederick Andermann

Subsection 4.1 Precipitating factors
89. Fever
Thomas Bleck

90. The menstrual cycle and catamenial epilepsy
Andrew Herzog

91. Sleep
Liborio Parrino, Giulia Milioli, Fernado De Paolis, Andrea Grassi, Gioia Gioi, Mario Giovanni Terzano

92. Metabolic and endocrine-induced seizures
Bernhard Steinhoff

93. Electrolyte or sugar disturbances
Bindu Menon, Simon Shorvon

94. Drug-induced seizures
Aidan Neligan

95. Alcohol and toxin-induced seizures
Michelle Shapiro, Andrew Cole

Subsection 4.2 – Reflex seizures
96. How reflex mechanisms cause epilepsy
Benjamin Zifkin, Frederick Andermann

97. Visual stimuli, photosensitivity and photosensitive epilepsy
Dorothée KAsteleijn-Nolst Trenité, Laura Cantonetti, Pasquale Parisi

98. Startle-induced (and other sensory induced) epilepsy
Jean-Pierre Vignal , Andrine Aubert, Patrick Chauvel

99. Primary reading epilepsy
Matthias Koepp

100. Auditory-induced epilepsy
Carlo Di Bonaventura, Frederick Andermann

101. Focal reflex seizures – with emphasis on epilepsy triggered by eating
Benjamin Zifkin, Guy Rémillard, Frederick Andermann

102. Hot water epilepsy
P Satischandra, S Sinha, Anuranjan Anand

103. Reflex epilepsy with higher-level processing
Benjamin Zifkin, Frederick Andermann

Section 5 – Status Epilepticus
104. Introduction – how status epilepticus is caused
Karthik Rajasekaran, Howard Goodkin

105. Causes of status epilepticus in children
Rodd Scott

106. The causes of convulsive status epilepticus in adults
Elizabeth Waterhouse, Peter Kaplan

107. Uncommon causes of status epilepticus
Simon Shorvon, Raymond Tan, Aidan Neilgan

108. Causes of non-convulsive status epilepticus in adults
Pierre Thomas

109. Causes of epilepsia partialis continua
Hirokazu Oguni and Frederick Andermann

100. Afterword
Simon Shorvon, Renzo Guerrini, Frederick Andermann