Category: 2016

Neurology: A Queen Square Textbook (2nd Edition)

Neurology: A Queen Square Textbook (2nd Edition)

Charles Clarke, Robin Howard, Martin Rossor, Simon Shorvon
Wiley Blackwell, 2016
ISBN: 978-1-118-48617-7
1096 pages


Neurology: A Queen Square Textbook, second edition, is a fully revised and updated companion that demonstrates the rapid pace of advancement within clinical neurology and applied neurosciences

  • A comprehensive and practical overview of current developments within clinical neurology, synthesising clinical neurology with translational research
  • Expertly edited and written by neurologists, neuroscientists and neurosurgeons working at Queen Square, advised by an distinguished International Editor team to present a global perspective
  • Introductory chapters summarise the basic sciences underpinning the practice of clinical neurology, including genetics, channelopathies, immunology, neurophysiology and neuropathology
  • All chapters fully revised and updated to reflect the increasing role of neurologists in acute care
  • Includes new contributions concerning major developments in the care of; stroke, epilepsy, dementia, Parkinson’s disease, multiple sclerosis, neuromuscular disease, headache, infections, spinal disease, cranial nerve disease, neuropsychiatry, neurogenetics, neuro-oncology, uroneurology, neuro-otology, neuro-ophthalmology, pain medicine, sleep medicine, metabolic disease, drugs and toxins, autonomic disease, systemic disease, and neurorehabilitation for dementia, epilepsy, headaches, neuro-genetics and many more

Table of Contents

1 Neurology Worldwide: The Epidemiology and Burden of Neurological Disease
Simon Shorvon

2 Nervous System Structure and Function
Charles Clarke and Roger Lemon

3 Mechanisms of Neurological Disease: Genetics, Autoimmunity and Ion Channels
Dimitri Kullmann, Henry Houlden and Michael Lunn

4 The Language of Neurology: Symptoms, Signs and Basic Investigations
Charles Clarke, Matthew Adams, Robin Howard, Martin Rossor, Simon Shorvon and Jason Warren

5 Stroke and Cerebrovascular Diseases
Nicholas Losseff, Matthew Adams, Martin M. Brown, Joan Grieve and Robert Simister

6 Movement Disorders
Kailash Bhatia, Carla Cordivari, Mark Edwards, Thomas Foltynie, Marwan Hariz, Prasad Korlipara, Patricia Limousin, Niall Quinn, Sarah Tabrizi and Thomas Warner

7 Epilepsy and Related Disorders
Simon Shorvon, Beate Diehl, John Duncan, Matthias Koepp, Fergus Rugg-Gunn, Josemir Sander, Matthew Walker and Tim Wehner

8 Dementia and Cognitive Impairment
Martin Rossor, John Collinge, Nick Fox, Simon Mead, Catherine Mummery, Jonathan Rohrer, Jonathan Schott and Jason Warren

9 Infection in the Nervous System
Robin Howard, Carmel Curtis and Hadi Manji

10 Nerve and Muscle Disease
Michael Lunn, Michael Hanna, Robin Howard, Matthew Parton, Shamima Rahman, Mary Reilly, Katie Sidle and Christopher Turner

11 Multiple Sclerosis and Demyelinating Diseases
Siobhan Leary, Gavin Giovannoni, Robin Howard, David Miller and Alan Thompson

12 Headache
Manjit Matharu, Paul Shanahan and Tim Young

13 Cranial Nerve Disorders
Jeremy Chataway, Charles Clarke, Robin Howard and Paul Jarman

14 Neuro-ophthalmology
James Acheson, Fion Bremner, Elizabeth Graham, Robin Howard, Alexander Leff, Gordon Plant, Simon Shorvon and Ahmed Toosy

15 Neuro-0tology: Problems of Dizziness, Balance and Hearing
Rosalyn Davies, Linda M. Luxon, Doris ]Eva Bamiou and Adolfo Bronstein

16 Spinal Column and Spinal Cord Disorders
Simon Farmer and David Choi

17 Cerebellar Ataxias and Related Conditions
Nicholas W. Wood

18 Restorative Neurology, Rehabilitation and Brain Injury
Richard Greenwood, Diana Caine, Ulrike Hammerbeck, Alexander Leff, Diane Playford, Valerie Stevenson and Nick Ward

19 Toxic, Metabolic and Physical Insults to the Nervous System and Inherited Disorders of Metabolism
Robin Howard, Jeremy Chataway, Mark Edwards, Simon Heales, Robin Lachmann, Alexander Leff and Elaine Murphy

20 Disorders of Consciousness, Intensive Care Neurology and Sleep
Robin Howard, Sofia Eriksson, Nicholas Hirsch, Neil Kitchen, Dimitri Kullmann, Christopher Taylor and Matthew Walker

21 Neuro-oncology
Jeremy Rees, Robert Bradford, Sebastian Brandner, Naomi Fersht, Rolf Jäger and Elena Wilson

22 Neuropsychiatry
Eileen Joyce

23 Pain
Paul Nandi

24 Autonomic Aspects of Neurology
Christopher Mathias, Gordon Ingle and Valeria Iodice

25 Uroneurology
Jalesh Panicker

26 Systemic Conditions and Neurology
David Werring, Robin Howard and Simon Shorvon

Index 1029

Physicians and War

Physicians and War

Humphrey Hodgson and Simon Shorvon
Little Brown 2016
ISBN-10: 1408706288; ISBN9781408706282
112 pages


The Royal College of Physicians celebrates its 500th anniversary in 2018, and to observe this landmark is publishing a series of ten books. Each of the books focuses on fifty elements that have contributed to making the RCP what it is today.  This, the fourth book, outlines some of the effects of war on the College as an institution, on it’s buildings and especially on its members and fellows. Medicine can profoundly change the fortunes of those engaged in war, and war also greatly changes medicine. It creates new diseases, leads to medical innovation and advances in therapy, and has also stimulated new approaches to the organisation of medical care. This book is a brief exposition on aspects of the complex interface of war and medicine, and the crucial role played by the College and its physicians in the medicine of war.

Table of Contents


The turbulent seventeenth century

Napoleonic wars and the alter nineteenth century

World War I

World War II


The End of Epilepsy?: A history of the modern era of epilepsy research 1860-2010

The End of Epilepsy?: A history of the modern era of epilepsy research 1860-2010

Dieter Schmidt and Simon Shorvon
Oxford University Press, 2016
ISBN-10: 0198725906; ISBN-13: 9780198725909
208 pages


Epilepsy is more than just a physical condition, the fact of simply having epileptic seizures, it has cultural, geographic and historical meaning and significance which go beyond that of a neurological disorder, and which defy a single perspective. The End of Epilepsy? is a beautifully illustrated, authoritative, and engaging history of medical developments during the modern era of epilepsy, which began with the introduction of Bromides and Hughlings-Jacksons definition of epilepsy in 1860.

Table of Contents

1: What is epilepsy?
2: Attitudes
3: The pharmaceutical phoenix rises
4: Modern blockbusters
5: Resecting epilepsy
6: The dark side of epilepsy
7: Culs-de-sac and bureaucracies
8: Is the end of epilepsy in sight?
Appendix: Dating epilepsy




The Treatment of Epilepsy (4th Edition)

The Treatment of Epilepsy (4th Edition)

Simon Shorvon, Emilio Perucca, Jerome Engel (eds) 
2016, Wiley-Blackwell | ISBN 978-1-118-93700-6 | pp 1072

The Treatment of Epilepsy, fourth edition, is a comprehensive reference and clinical guide to the
pharmacological, medical and surgical options available in the treatment of epilepsy.
Its features include:

The text is compiled by a group of internationally renowned editors and contributors and
is now in full color and extensively illustrated
The first two sections cover the background to, and principles of, treatment in different
clinical situations
Section three comprises a series of systematic reviews of contemporary drug therapy,
devoting one chapter to each anti-epileptic drug and covering all clinically-relevant aspects
Section four focuses on the surgical options, devoting individual chapters to each of the
modalities of presurgical assessment and to each surgical operation or approach
This 4th edition is extensively revised incorporating the many recent developments in
therapy, and comprises 81 chapters from world experts from 18 countries



List of Contributors v
Preface to the Fourth Edition ix
Preface to the First Edition xi

Historical Introduction
The Drug Treatment of Epilepsy from 1857 to 2015 xiii
Simon Shorvon

Section I – Introdution
1 Definition (Terminology) and Classification in Epilepsy: A Historical Survey and Current Formulation,
with Special Reference to the ILAE 1
Simon Shorvon

2 Differential Diagnosis of Epilepsy 24
Mark Cook

3 Mechanisms of Epileptogenesis 38
Giuliano Avanzini and Silvana Franceschetti

4 Antiepileptic Drug Discovery 52
H. Steve White and Melissa Barker-Haliski

5 Antiepileptic Drug Development 61
Dieter Schmidt

6 Mechanisms of Antiepileptic Drug Action 75
Matthew C. Walker and Rainer Surges

7 Mechanisms of Drug Resistance and Tolerance 92
Wolfgang Löscher and Dieter Schmidt

8 Epilepsy Biomarkers 103
Jerome Engel, Jr. and Asla Pitkänen

Section II – Principles of Medical Management
9 General Principles of Medical Management 110
Emilio Perucca

10 Pharmacokinetic Optimization of Therapy 124
Svein I. Johannessen, Cecilie Johannessen Landmark and Emilio Perucca

11 Management of Chronic Active Epilepsy in Adults 139
Simon Shorvon

12 Management of Epilepsy in Remission 148
Patrick Kwan, Howan Leung and Xiaoting Hao

13 Management of Epilepsy in Neonates and Infants 156
Elissa G. Yozawitz and Solomon L. Moshé

14 Management of Childhood Epilepsy Syndromes 174
Colin D. Ferrie

15 Management of Epilepsy in People with Intellectual Disabilities 193
Eylert Brodtkorb

16 Management of Epilepsy in the Elderly 205
Hiba Arif Haider and Lawrence J. Hirsch

17 Emergency Treatment of Seizures and Status Epilepticus 221
Matthew C. Walker and Simon Shorvon

18 Management of Medical Comorbidity Associated with Epilepsy 245
Gagandeep Singh

19 Psychiatric Features of Epilepsy and their Management 259
Brent Elliott and Simon Shorvon

20 Prevention and Management of Side-effects of Antiepileptic Drugs 275
Gaetano Zaccara and Piero Perucca

21 Ketogenic Diets 288
Eric H. Kossoff and Courtney A. Haney

22 Complementary and Alternative Treatments for Epilepsy 298
Sallie Baxendale

23 Reproductive Aspects of Epilepsy Treatment 311
Torbjörn Tomson

24 Genetic Counselling in Epilepsy 323
Federico Zara

25 Drug Interactions 344
Edoardo Spina and Domenico Italiano

26 Medical Treatment of Epilepsy in Resource-Poor Countries 360
Patrick Adjei

Section III – Antiepileptic Drugs
27 Introduction to the Choice of Antiepileptic Drugs 365
Emilio Perucca

28 Acetazolamide 376
Miri Y. Neufeld

29 Adrenocorticotropic Hormone and Corticosteroids 388
Federico Vigevano and Maria Roberta Cilio

30 Benzodiazepines Used in the Treatment of Epilepsy 398
Eugen Trinka and Francesco Brigo

31 Brivaracetam 418
Joseph D’Souza and Emilio Perucca

32 Carbamazepine 431
Torbjörn Tomson and Svein I. Johannessen

33 Eslicarbazepine Acetate 447
Meir Bialer and Christian Elger

34 Ethosuximide 460
Tracy A. Glauser and Emilio Perucca

35 Felbamate 472
Ilo E. Leppik and James R. White

36 Gabapentin 479
Ernest R. Somerville, Andrew W. Michell and Arjune Sen

37 Lacosamide 489
Rajesh Sachdeo and Roopal Karia

38 Lamotrigine 498
Awais Riaz and Fumisuke Matsuo

39 Levetiracetam 516
Derek J. Chong and Jacqueline A. French

40 Oxcarbazepine 533
Edward Faught and Hyunmi Kim

41 Perampanel 546
Martin Brodie

42 Phenobarbital, Primidone and Other Barbiturates 555
Roberto Michelucci and Elena Pasini

43 Phenytoin 574
Mervyn J. Eadie

44 Piracetam 589
Simon D. Shorvon

45 Pregabalin 595
Sylvain Rheims and Philippe Ryvlin

46 Retigabine 606
Michel Baulac

47 Rufinamide 617
Victor Biton

48 Stiripentol 628
Tapani Keränen

49 Tiagabine 633
Reetta Kälviäinen

50 Topiramate 642
J. Helen Cross and Catherine J. Riney

51 Valproate 652
Anthony G. Marson and Graeme J. Sills

52 Vigabatrin 667
Günter Krämer and Gabriele Ch. Wohlrab

53 Zonisamide 680
Michel Baulac

54 Other Less Commonly Used Antiepileptic Drugs 689
Martin Holtkamp

55 Drugs in Clinical Development 701
Norman Delanty and H. Steve White

Section IV – Presurgical Assessment and Epilepsy Surgery
56 Overview of Surgical Treatment for Epilepsy 709
Jerome Engel, Jr.

57 Scalp EEG in the Epilepsy Surgery Evaluation 723
Christine B. Baca and John M. Stern

58 Invasive EEG in Presurgical Evaluation of Epilepsy 733
Dennis Spencer, Dang K. Nguyen and Adithya Sivaraju

59 MEG in Epilepsy Surgery Evaluation 756
Hermann Stefan and Paul Boon

60 MRI in Presurgical Evaluation 764
Christian E. Elger and Bernd Weber

61 PET and SPECT in Presurgical Evaluation of Epilepsy 775
Karolien Goffin and Wim Van Paesschen

62 Special Neurophysiological Techniques 787
François Mauguière and Julien Jung

63 Neuropsychological Testing in Presurgical Evaluation 804
Marilyn Jones-Gotman and Gail L. Risse

64 Presurgical Psychiatric Evaluation 817
Andres M. Kanner

65 Mesial Temporal Lobe Surgery and Other Lobar Resections 829
James Leiphart and Itzhak Fried

66 Resective Surgery of Neoplasms 842
Nicholas M. Wetjen and Gregory D. Cascino

67 Resective Surgery of Vascular and Infective Lesions for Epilepsy 858
Christopher E. Uff and Neil D. Kitchen

68 Surgery of Developmental Anomalies Causing Epilepsy 878
Ahyuda Oh, Joshua J. Chern and Youssef G. Comair

69 Hemispheric Operations for Epilepsy 887
Georg Dorfmüller, Christine Bulteau and Olivier Delalande

70 Corpus Callosum Operations 895
David W. Roberts

71 Hypothalamic Hamartoma 903
John F. Kerrigan

72 Multiple Subpial Transection 916
Adriana Bermeo-Ovalle and Michael C. Smith

73 Awake Surgery for Epilepsy 922
Webster H. Pilcher

74 Epilepsy Surgery in Children 931
Jason S. Hauptman and Gary W. Mathern

75 Complications of Epilepsy Surgery 941
Charles E. Polkey

76 Anaesthesia for Epilepsy Surgery 952
Barbara M. Van de Wiele

77 Vagus and Trigeminal Nerve Stimulation 959
Steven C. Schachter

78 Brain Stimulation for Epilepsy 967
Gregory K. Bergey and Robert S. Fisher

79 Non-Resective Approaches for Medically Intractable Epilepsy 980
Thomas J. Gianaris, Andrea G. Scherer and Nicholas M. Barbaro

80 Future Focal Treatment Approaches to Epilepsy 987
Laura Mantoan Ritter and Hannah Cock

81 Epilepsy Surgery in Countries with Limited Resources 999
Andre Palmini and Kurupath Radhakrishnan


Index 1008