Category: 2009

Epilepsy (Oxford Neurology Library Series)

Epilepsy (Oxford Neurology Library Series)

Simon Shorvon 
Oxford University Press, Oxford. 2009. | ISBN 978-0-19-957692-0 |pp. 172

This book is part of the Oxford Neurology Library. It aims to be a concise pocketbook for the practicing clinician. The purpose of the book volume is to provide a short but comprehensive survey of epilepsy and its management for the busy clinician. It is very definitely intended to be a clinical tool—and what is provided is clinical information rather than data relevant to research or experimental study. Factual information is contained as much as possible, in a digestible form, and to avoid longwinded or complex description. Diagnosis, treatment and counselling are especially emphasized, for it is in these areas that accurate data and clinical skill are particularly needed. Pharmacological, pharmacokinetic and therapeutic details of individual drugs are summarized in tables for rapid reference. Emergency and surgical therapies for epilepsy are also covered. The book is designed for generalists, specialists and trainees.



Preface vi
Symbols and abbreviations vii
1.Definition and frequency of epilepsy 1
2. Clinical forms of epilepsy 7
3. The causes of epilepsy 29
4. The differential diagnosis and investigation of epilepsy 49
5. Principles of treatment of epilepsy 65
6.Anti-epileptic drugs 91
7. Epilepsy surgery 123
8. Emergency treatment of epileptic seizures 139
9. Social and psychosocial aspects of epilepsy 153
Index 167

The Epilepsies 3

The Epilepsies 3

Edited by Simon Shorvon and Timothy A. Pedley 
Saunders, Philadelphia, 2009. 
355 pages 38 ills | Trim size 6 X 9 in | ISBN: 1405131349

This title in the Blue Books of Neurology series highlights advances in epileptology and new ways of managing seizure disorders. Contributors from around the world lend a global perspective. The chapters are focused on areas in which there are significant new findings or those that are controversial. Basic research and clinical topics are included. There are detailed discussions of difficulties in diagnosing and treating epilepsy, including the latest pharmacologic management strategies.


1. Seizure Prediction: Its Evolution and Therapeutic Potential. pp1-16
David Kreiger and Brian Litt

2. Febrile Seizures. pp 17-26
Celine M Dube and Tallie Z Baram
3. Mechanisms of Action of Levetiracetam and Newer SV2A Ligands. pp 27-38
Henrik Klitgaard and Alain Matagne

4. Long-Term Effects of Seizures on Brain Structure and Function. pp 39-52
Howard F Goodkin and Edward H Bertram

5. Dipole Source Modeling in Epilepsy: Contribution to Clinical Management. pp 53-64
John S Ebersole

6. EEG-correlated fMRI in Epilepsy: current state of the art. pp 65-83
Rachel Thornton and Louis Lemieux

7. Epilepsy and Sleep. pp 84-96
Soheyl Noachtar and Jan Remi

8. Cortical Myoclonus and Epilepsy: Overlap and Differences. pp 97-118
Renzo Guerrini and Francesco Mari

9. The Life-Threatening Epilepsies of Childhood and Their Treatment. pp 119-128
Catherine Chiron

10. The Spectrum of Epilepsies Associated with Generalized Spike and Wave Patterns. pp 129-144
Michael Koutroumanidas and Chrysostomos Panayiotopoulos

11. Epilepsies due to Monogenic Disorders of Metabolism. pp 145- 160
Chantal Depondt

12. Rasmussen’s Encephalitis. pp 161-176
Tiziana Granata and Carlo Antozzi

13. Seizures and Epilepsy in the Elderly. pp 177-193
Ann Mendiratta and Timothy Pedley

14. Psychosis of Epilepsy. pp 194-210
Andres M Kanner

15. Sudden Unexpected Death in Epilepsy. pp 211-240
Fergus Rugg-Gunn and Lina Nashef

16. The Management of Epilepsy in Pregnancy. pp 241-264
Torbjorn Tomson and Dina Battino

17. Does Early Treatment Influence the Long-Term Outcome of Epilepsy. pp 265-276
Anthony Marson

18. Pharmacodynamic Interactions of Antiepileptic Drugs. pp 277-293
Gail D Anderson and Jong M Rho

19. The Surgery of Temporal Lobe Epilepsy I – Historical Development, Patient Selection, and Seizure Outcome. pp 294-306
Nicholas Moran and Simon Shorvon

20. The Surgery of Temporal Lobe Epilepsy II – Surgical Complications and Long-Term Adverse Effects. pp 307-321
Simon Shorvon and Nicholas Moran

21. Brain Stimulation in Epilepsy – An Old Technique with a New Promise? pp 322-241
Kristl Vonck and Paul Boon

International League Against Epilepsy (1909-2009)

International League Against Epilepsy (1909-2009)

Simon Shorvon, Giselle Weiss, Giuliano Avanzini, Jerome Engel, Harry Meinardi, Solomon Moshe, Edward Reynolds, Peter Wolf. 
Wiley-Blackwell, 2009. | pp. 338. | ISBN 9781405 1895520

The International League Against Epilepsy (the ILAE) was founded on August 30th 1909, and is one of the oldest international subspecialist organisations in medicine. This book is published to mark its centenary, with the aims of documenting its course over its first 100 years, of interpreting its activities within their historical context, and of assembling source material.

The book is the result of a large amount of original research from published and unpublished written material and from the verbal recollections and experiences of individuals within the organisation. The text attempts to provide a scholarly, lively and instructive history, which is the definitive account of an organisation whose goal throughout its 100 year history has been to work towards the alleviation of the suffering caused by epilepsy around the world.

The authors of this book have held various positions on the ILAE executive. Giuliano Avanzini and Jerome Engel have each served both as Treasurer and President of the ILAE; Harry Meinardi was previously ILAE Secretary-General and President; Solomon Moshé is currently Secretary-General and President-elect of the ILAE; Edward Reynolds was a previous ILAE President; Peter Wolf is currently President and has been Secretary General of the ILAE; Simon Shorvon serves currently as co-Editor-in-Chief of Epilepsia and was previously ILAE Information Officer and Vice- President. Giselle Weis is the Centenary Archivist of the League.



Preface, viii – xix
Simon Shorvon

Introduction, x-xiv
Simon Shorvon

1. International League Against Epilepsy – the first period: 1909–1952, 1
Simon Shorvon and Giselle Weiss

2. International League Against Epilepsy – the second period: 1953–1992. pp 45 – 98
Giselle Weiss and Simon Shorvon

3. International League Against Epilepsy – the third period: 1993– 2009. pp 97 – 130
Giuliano Avanzini, Jerome Engel, Jr., Edward Reynolds, Simon Shorvon,Giselle Weiss and Peter Wolf

4. Development of the classification and nosology of epilepsy 1909–2009, pp 131 – 142
Peter Wolf

5. Organisation of basic science in epilepsy with special reference to the International League Against Epilepsy, pp 143 – 152
Jerome Engel, Jr., Solomon Moshé and Giuliano Avanzini

6.The relations of the International League Against Epilepsy with the lay organisations, pp 153 – 162
Harry Meinardi

7. Epilepsia – the journal of the International League Against Epilepsy, pp 163 – 206
Simon Shorvon

8. International League Against Epilepsy – commissions, task forces and the Global Campaign Against Epilepsy, pp 207 – 215
Peter Wolf and Edward Reynolds

9. International League Against Epilepsy – the international symposia and congresses, 1909–2009, p 216 – 254
Giselle Weiss and Simon Shorvon

Appendix 1 ILAE Chapters and dates of incorporation, 255
Appendix 2 ILAE Executive Committee membership, 259
Appendix 3 ILAE Commission membership, 263
Appendix 4 ILAE Financial statements, 273
Appendix 5 ILAE Constitutions and Bylaws, 289
Appendix 6 ILAE Ambassadors for Epilepsy, 1968–present, 309
Giselle Weiss

Neurology: A Queen Square Textbook

Neurology: A Queen Square Textbook

Eds: Clarke C, Howard R, Shorvon S, Rossor M 
Wiley-Blackwell, Oxford. 
991 Pages | ISBN-10: 1-4051-3443-7 | ISBN-13: 978-1-4051-3443-9

This is a textbook of neurology from the UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery at Queen Square, London, and content based on the neurological training programme.

The book attempts to blend clinical and basic neuroscience, particularly in relation to molecular biology, genetics, neurochemistry and physiology. The book presents a synthesis of modern science with traditional clinical neurology rooted in history taking and the meticulous elicitation of physical signs.



1. Neurology Worldwide: the Burden of Neurological Disease. pp 1 – 12
Simon Shorvon

2. Nervous System Structure and Function. pp 13 – 74
Charles Clarke and Roger Lemon

3. The Language of Neurology: Symptoms, Signs and Basic Investigations. pp 75 – 108
Charles Clarke, Richard Fracknowiak, Robin Howard, Martin Rossor and Simon Shorvon

4. Stroke and Cerebrovascular Diseases. pp 109 – 154
Nicholas Lossef, Martin Brown and Joan Grieve

5. Movement Disorders. pp 155 – 189
Niall Quinn, Kailash Bhatia, Peter Brown, Carla Cordivari, MArwan Hariz, Andrew Lees, Patricia Limousin, Mary Robertson, Anette Schrag, Sarah Tabrizi

6. Epilepsy and Related Disorders. pp 198 – 244
Simon Shorvon, John Duncan, Mathias Koepp, Josemir Sander, Shelagh Smith, Matthew Walker

7. Cognitive Impairment and Dementia. pp 245 – 288
Martin Rossor, John Collinge, Nick Foz, Robin Howard, Giovanni Mallucci, Catherine Mummery, Jason Warren

8. Infection in the Nervous System. pp 289 – 336
Robin Howard and Hadi Manji

9. Nerve and Muscle Disease. pp 227 – 410
Michael Lunn, Michael Hanna, Robin Howard, Matthew Parton, Mary Reilly

10. Multiple Sclerosis and Demyelinating Diseases. pp 411 – 448
Siobhan Leary, Gavin Giovannoni, Robin Howard, David Miller, Alan Thompson

11. Headache. pp 449 – 464
Peter Goadsby

12. Cranial Nerve Disorders. pp 465 – 488
Paul jarman, Jeremy Chataway, Charles Clarke, Robin Howard

13. Neuro-ophthalmology. pp 489 – 532
Gordon Plant, James Acheson, Charles Clarke, Elizabeth Graham, Robin Howard, Simon Shorvon

14. Neuro-otology. pp 533 – 584
Rosalyn Davies, Linda Luxon, Doris-Eva Bamiou, Simon Shorvon

15. Spinal Cord Disorders. pp 585 – 628
Simon Farmer, Adrian Casey, David Choi, Robin Howard, Geoffrey Raisman

16. Cerebellar Ataxias and Related Conditions. pp 629 – 644
Nicholas Wood

17. Restorative and rehabilitation neurology. pp 645 – 676
Richard Greenwood, Jan Marsden, Diane Playford, Valerie Stevenson, Nick Ward

18. Toxic, Metabolic and Physical Insults to the Nervous System and inborn errors of metabolism. pp 675 – 722
Robin Howard, Robin Lachmann, Philip Lee, Alexander Leff

19. Disorders of Consciousness, Intensive Care Neurology and Sleep. pp 723 – 770
Robin Howard, Nicholas Hirsch, Neil Kitchen, Dimitri Kullmann, Matthew Walker

20. Neuro-oncology. pp 771 – 822
Jeremy Rees, Sebastian Brandner, Robin Howard, Rolf Jager, Susan Short, David Thomas, Emma Townsley, Gelareh Zadeh

21. Psychiatry and Neurology. pp 823-846
Michael Trimble

22. Pain. pp 847 – 870
Geoffrey Schott

23. Autonomic Dysfunction. pp 871 – 892
Christopher Matthias

24. Uro-neurology. pp 893 – 912
Clare Fowler, Sohier Elneil

25. Systemic Conditions and Neurology. pp 913 – 944
David Werring, Robin Howard, Alexander Leff, Simon Shorvon

Treatment of Epilepsy (3rd Edition)

Treatment of Epilepsy (3rd Edition)

Simon Shorvon, Emilio Perucca, Jerome Engel (Editors) 
Wiley-Blackwell, Oxford (2009). | ISBN 978-1-4051-8383-3 | pp 1200

This is a textbook of epilepsy treatment, in its third edition and considered a standard reference work worldwide. Its primary objective is to provide a systematic review of the whole field of contemporary therapy in epilepsy. The emphasis is, as before, on a text that provides practical information, useful for the clinician but which is comprehensive, accurate and concisely given. The basic purpose of the book to guide clinical practice and rational therapy, and to be a source of reference for clinicians at every level.

The book has a new editor and has increased in size from 63 in the first edition, to 74 in the second and to 85 in this edition. There are 26 completely new chapters, as well as extensive updating of the others. There are 90 new authors, joining the 53 who contributed to both this and the previous edition. The new chapters reflect the significant changes which have been made to the principles of, and approaches to, epilepsy therapy, the introduction of new drugs and the development of new surgical techniques.

The three editors are, or have been, long-standing members of the ILAE executive and almost all of the lead authors of the chapters of our book are involved deeply in the league. Indeed, contributors to the book are from 17 countries in all five continents, reflecting the global reach.

In the historical introduction to this edition, the historical survey of drug therapy in epilepsy is continued, bringing this up to the year 1989. In the previous two editions, the survey covered the years 1857– 1938 and then 1938–1955. Here, the story is advanced by 35 important years to 1989, and is written from the particular perspective of the ILAE.


Forword, xv
Preface to the Third Edition, xvii
Historical introduction: History of the Drug Treatment of Epilepsy Between 1955 and 1989 with Special Reference to the Role of the International League Against Epilepsy (ILAE), xxi
Simon Shorvon

Section 1 – Introdution
1. Definitions and Classification of Epilepsy, 3 1
Christina A. Gurnett and W. Edwin Dodson

2. Epidemiology and Prognosis of Epilepsy, 21
Lars Forsgren and Dale Hesdorffer

3. Aetiology of Epilepsy, 33
Simon D. Shorvon

4.Differential Diagnosis of Epilepsy, 55
Mark Cook

5. Mechanisms of Epileptogenesis, 67
Giuliano Avanzini and Silvana Franceschetti

6.Antiepileptic Drug Discovery, 81
H. Steve White

7. Mechanisms of Antiepileptic Drug Action, 91
Matthew C. Walker, Rainer Surges and Andrew Fisher

8. Mechanisms of Tolerance and Drug Resistance, 109
Wolfgang Löscher and Dieter Schmidt

Section 2 – Principles of Medical Management
9. General Principles of Medical Management, 121
Emilio Perucca

10 Management of Newly Diagnosed Epilepsy, 141
Yvonne M. Hart

11 Management of Chronic Active Epilepsy in Adults, 153
Simon D. Shorvon

12 Management of Epilepsy in Remission, 163
Patrick Kwan and Howan Leung

13 Management of Epilepsy in Infants, 171
Catherine Chiron

14 Management of Childhood Epilepsy Syndromes, 179
Colin D. Ferrie

15 Management of Epilepsies Associated with Specific Diseases in Children, 195
John H. Livingston

16 Management of Epilepsy in the Elderly, 203
Hiba Arif, Anil Mendiratta and Lawrence J. Hirsch

17 Management of Epilepsy in People with Learning Disabilities, 219
Eylert Brodtkorb

18 Emergency Treatment of Seizures and Status Epilepticus, 231
Matthew C. Walker and Simon D. Shorvon

19 Traumatic Brain Injury and Other Risks, 249
Marc Dichter and Nancy R. Temkin

20 Management of Medical Co-morbidity Associated with Epilepsy, 259
Gagandeep Singh

21 Psychiatric Features of Epilepsy and their
Brent Elliott, Meriem Amarouche and Simon D. Shorvon

22 Management of Side-effects of Antiepileptic Drugs, 28
Gaetano Zaccara, Fabrizio Balestrieri and Aldo Ragazzoni

23 Ketogenic Diets, 301
Eric H. Kossoff and Jennifer L. Dorward

24 Non-pharmacological, Complementary and Alternative Treatments for Epilepsy, 311
Tom Whitmarsh

25 Reproductive Aspects of Epilepsy Treatment, 323
Torbjörn Tomson

26 Epilepsy Counselling, 335
Anthony Linklater, Doreen Patsika and Susan Usiskin

27 Genetic Counselling in Epilepsy, 341
Federico Zara

28 Drug Interactions, 361
Edoardo Spina

29 Medical Treatment of Epilepsy in Situations with Limited Resources, 379
Gretchen L. Birbeck

Section 3 – Antiepileptic Drugs
30 Introduction to the Choice of Antiepileptic Drugs, 389
Emilio Perucca

31 Acetazolamide, 399
Miri Y. Neufeld

32 Adrenocorticotropic Hormone and Corticosteroids, 411
Federico Vigevano and Maria Roberta Cilio

33. Benzodiazepines used Primarily for Chronic Treatment (Clobazam, Clonazepam, Clorazepate and Nitrazepam), 459
Peter Camfield and Carol Camfield

34 Benzodiazepines used Primarily for Emergency Treatment (Diazepam, Lorazepam and Midazolam), 469
Eugen Trinka

35 Brivaracetam, 421
Philipp von Rosenstiel and Emilio Perucca

36 Carbamazepine, 443
Matti Sillanpää, Leena Haataja, Torbjörn Tomson and Svein I. Johannessen

37 Carisbamate, 433
Gerald P. Novak and Martin J. Brodie

38 Eslicarbazepine Acetate, 485
Luis Almeida, Meir Bialer and Patricio Soares-da-Silva

39 Ethosuximide, 499
Tracy A. Glauser and Emilio Perucca

40 Felbamate, 511
Ilo E. Leppik and James R. White

41 Gabapentin, 519
Ernest R. Somerville and Andrew W. Michell

42 Lacosamide, 527
Rajesh Sachdeo

43 Lamotrigine, 535
Fumisuke Matsuo and Awais Riaz

44 Levetiracetam, 559
Jacqueline A. French and Françoise Tonner

45 Oxcarbazepine, 575
Edward Faught and Nita Limdi

46 Phenobarbital, Primidone and Other Barbiturates, 585
Roberto Michelucci, Elena Pasini and Carlo Alberto Tassinari

47 Phenytoin, 605
Mervyn J. Eadie

48 Piracetam, 619
Simon D. Shorvon

49 Pregabalin, 627
Sylvain Rheims and Philippe Ryvlin

50 Retigabine, 637
Harry Mansbach and Michel Baulac

51 Rufinamide, 647
Victor Biton

52 Stiripentol, 657
Kai Eriksson and Tapani Keränen

53 Tiagabine, 663
Reetta Kälviäinen

54 Topiramate, 673
J. Helen Cross and Catherine J. Riney

55 Valproate, 685
Blaise F.D. Bourgeois

56 Vigabatrin, 699
Günter Krämer and Gabriele Wohlrab

57 Zonisamide, 713
Stephen J. Wroe

58 Other Drugs Rarely Used, 721
Hartmut Meierkord and Martin Holtkamp

59 Antiepileptic Drugs in Early Clinical Development, 733
Philip N. Patsalos and Josemir W. Sander

Section 4 – Presurgical Assessment and Epilepsy Surgery
60 Overview of Surgical Treatment for Epilepsy, 743
Jerome Engel Jr

61 Scalp EEG in the Epilepsy Surgery Evaluation, 757
Christine Bower Baca and John M. Stern

62 Invasive EEG in Presurgical Evaluation of Epilepsy, 767
Susan S. Spencer, Dang K. Nguyen and Robert B. Duckrow

63 MEG in Presurgical Evaluation of Epilepsy, 799
Hermann Stefan, Stefan Rampp and Rüdiger Hopfengärtner

64 MRI in the Presurgical Evaluation, 805
Jörg Wellmer and Christian E. Elger

65 PET and SPECT in Presurgical Evaluation of Epilepsy, 821
Wim Van Paesschen, Karolien Goffin and Koen Van Laere

66 Experimental Neurophysiological Techniques, 829
François Mauguière, Isabelle Merlet and Julien Jung

67 Neuropsychological Testing in Presurgical Evaluation, 851
Marilyn Jones-Gotman and Jelena Djordjevic

68 Presurgical Psychiatric Evaluation, 865
Andres M. Kanner

69 Mesial Temporal Lobe Surgery and Other Lobar Resections, 875
James Leiphart and Itzhak Fried

70 Resective Surgery of Neoplasms, 887
Nicholas Wetjen, Mithri R. Junna, Kurupath Radhakrishnan, Aaron Cohen-Gadol and Gregory D. Cascino

71 Resective Surgery of Vascular and Infective Lesions for Epilepsy, 903
Christopher E. Uff and Neil D. Kitchen

72 Surgery of Developmental Anomalies Causing Epilepsy, 925
Joshua Chern and Youssef G. Comair

73 Hemispherectomy for Epilepsy, 935
Georg Dorfmüller, Christine Bulteau and Olivier Delalande

74 Corpus Callosotomy, 943
David W. Roberts

75 Hypothalamic Hamartoma and Multiple Subpial Transection, 951
Michael C. Smith, Richard Byrne and Andres M. Kanner

76 Awake Surgery for Epilepsy, 959
Christian B. Kaufman and Webster H. Pilcher

77 Epilepsy Surgery in Children, 967
Jason S. Hauptman and Gary W. Mathern

78 Stereotactic Surgery for Epilepsy, 975
Andrew W. McEvoy and Fiona J.L. Arnold

79 Complications of Epilepsy Surgery, 993
Charles E. Polkey

80 Anaesthesia for Epilepsy Surgery, 1007
Barbara Van de Wiele

81 Vagal Nerve Stimulation, 1017
Steven C. Schachter

82 Brain Stimulation, 1025
Gregory K. Bergey

83 Stereotactic Radiosurgery for Medically Intractable Epilepsy, 1035
Isaac Yang, Edward F. Chang and Nicholas M. Barbaro

84 Future Focal Treatment Approaches to Epilepsy, 1043
Hannah R. Cock and Karen E. Nilsen

85 Epilepsy Surgery in Countries with Limited Resources, 1051
Andre Palmini

Index, 1057